[Exposure to chloroprene as an occupational hazard (a cohort epidemiologic study)]. / K voprosu o kantserogennoi opasnosti khloroprena v usloviiakh proizvodstva (kogortnoe èpidemiologicheskie issledovaniie.

A cancer epidemiological study was conducted in chloroprene workers in Yerevan. In a cohort of male workers, the total morbidity rates for all tumor patterns were significantly lower (32%) than expected, which was attributed to the effect of "the healthy worker". Risk for hepatic tumor was 3.83 times the expected level among male operators of the chloroprene production equipment. A direct "dose-effective" correlation was established between liver cancer risk and length of record for occupational exposure to chloroprene. The highest risk was among males who came into contact with the substance under the age of 30.

[Evaluation of antianginal effects of running pulse magnetic field and drug therapy on the physical working capacity and hemodynamics in patients with stable angina pectoris]. / Otsenka antianginal'nogo vliianiia begushchego impul'snogo magnitnogo polia i farmakoterapii na fizicheskuiu rabotosposobnost' i gemodinamiku u bol'nykh so stabil'noi stenokardiei.

The effects of the running pulse magnetic field, antianginal drug therapy and their combinations on the physical capacity were compared in 60 patients with Functional Classes I-III stable angina pectoris. Monotherapy with the running pulse magnetic field was found to produce an antianginal effect in patients with Functional Classes I-II angina pectoris, but the efficacy of drug therapy increased when antianginal drugs were used in combination with running pulse magnetic field in patients with severe angina.

Monosynaptic connections between LPa7-LPa3 and LPa9-LPa3 neurons in the central nervous system of helix pomatia. Electrophysiological characteristics, monosynaptic plasticity, neurotransmission.

Monosynaptic inputs from LPa7 and LPa9 cells onto the LPa3 neuron were investigated in the isolated central neurons system (CNS) of snail Helix by means of simultaneous intracellular recording from pre- and post-synaptic neurons and electrical stimulation of the presynaptic neuron through the recording microelectrode. Each action potential of either presynaptic cell produced excitatory postsynaptic potential (EPSP) in the follower one with an amplitude of 0.6-5 mV. Repetitive suprathreshold stimuli, applied at frequencies higher than 1 per 5 min, induced depression of the monosynaptic response. The cholinergic antagonists, atropine and d-tubocurarine (10(-6)M- 10(-4)M), dose-dependently inhibited monosynaptic EPSP from either presynaptic cell. Cholinergic transmission is suggested between LPa7-LPa3 and LPa9-LPa3 cells.

[Effect of beta-adrenergic blockaders and trental on plasma levels of renin and aldosterone in healthy persons during antiorthostatic hypokinesia]. / Vliianie beta-adrenergicheskikh blokatorov i trentala na soderzhanie renina i aldosterona v plazme krovi zdorovykh lits v usloviiakh antiortostaticheskoi gipokinezii.

Plasma renin activity and aldosterone levels were measured radioimmunologically in 30 normal individuals subjected to antiorthostatic hypokinesia (at a - 15 degrees angle). Hormonal effects of some drugs (beta-blockers, trental, venotonics) were examined. The short-term antiorthostatic position was associated with a disordered hormonal control, reduced plasma aldosterone and enhanced plasma renin activity, as compared to the respective parameters of the reclining position. The use of beta-adreno-blockers alone or in combinations with other drugs decreases plasma renin activity in conditions of antiorthostatic hypokinesia which can be related to the inhibition of beta-adrenergic activity.